In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer
نویسندگان
چکیده
منابع مشابه
Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer.
Employing in vitro selection techniques, we have generated biostable RNA-based compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently discovered endogenous ligand for the type 1a growth hormone secretagogue (GHS) receptor. Ghrelin is a potent stimulant of growth hormone release, food intake, and adiposity. We demonstrate that our lead compound, L-NOX-B11, bind...
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ژورنال
عنوان ژورنال: NeuroReport
سال: 2007
ISSN: 0959-4965
DOI: 10.1097/wnr.0b013e3282f1ab04